What is the universe made of?
How did life come about?
Are we alone in the universe?
What makes us human?
What is consciousness?
Why do we dream?
Why does matter exist?
Are there other universes?
Where will we put all the carbon?
How can we get more energy from the sun?
More at http://www.npr.org/blogs/13.7/2013/09/10/221019045/the-10-most-important-questions-in-science
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